Antibiotic Effects on Methicillin-Resistant Staphylococcus aureus Cytoplasmic Peptidoglycan Intermediate Levels and Evidence for Potential Metabolite Level Regulatory Loops

Cytoplasmic peptidoglycan (PG) precursor levels were determined in methicillin-resistant Staphylococcus aureus (MRSA) after exposure to several cell wall-targeting antibiotics. Three experiments were performed: (i) exposure to 4× MIC levels (acute); (ii) exposure to sub-MIC levels (subacute); (iii)...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Vemula, Harika, Ayon, Navid J., Burton, Alloch, Gutheil, William G.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2017
Subjects:
Mechanisms of Action: Physiological Effects
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444159/
https://ncbi.nlm.nih.gov/pubmed/28320719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02253-16
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