A Topical Hydrogel with Deferiprone and Gallium-Protoporphyrin Targets Bacterial Iron Metabolism and Has Antibiofilm Activity

Many infectious diseases are associated with multidrug-resistant (MDR) bacteria residing in biofilms that require high antibiotic concentrations. While oral drug delivery is frequently ineffective, topical treatments have the potential to deliver higher drug concentrations to the infection site whil...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Richter, Katharina, Thomas, Nicky, Claeys, Jolien, McGuane, Jonathan, Prestidge, Clive A., Coenye, Tom, Wormald, Peter-John, Vreugde, Sarah
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444117/
https://ncbi.nlm.nih.gov/pubmed/28396543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00481-17
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