Hepatic gene therapy rescues high-fat diet responses in circadian Clock mutant mice

OBJECTIVE: Circadian Clock gene mutant mice show dampened 24-h feeding rhythms and an increased sensitivity to high-fat diet (HFD) feeding. Restricting HFD access to the dark phase counteracts its obesogenic effect in wild-type mice. The extent to which altered feeding rhythms are causative for the...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Meyer-Kovac, Judit, Kolbe, Isa, Ehrhardt, Lea, Leliavski, Alexei, Husse, Jana, Salinas, Gabriela, Lingner, Thomas, Tsang, Anthony H., Barclay, Johanna L., Oster, Henrik
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444075/
https://ncbi.nlm.nih.gov/pubmed/28580282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2017.03.008
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