Dexamethasone protected human glioblastoma U87MG cells from temozolomide induced apoptosis by maintaining Bax:Bcl-2 ratio and preventing proteolytic activities

BACKGROUND: Glioblastoma is the deadliest and most prevalent brain tumor. Dexamethasone (DXM) is a commonly used steroid for treating glioblastoma patients for alleviation of vasogenic edema and pain prior to treatment with chemotherapeutic drugs. Temozolomide (TMZ), an alkylating agent, has recentl...

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Autores principales: Das, Arabinda, Banik, Naren L, Patel, Sunil J, Ray, Swapan K
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2004
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC544397/
https://ncbi.nlm.nih.gov/pubmed/15588281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-3-36
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