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Assembly of Huntingtin headpiece into α-helical bundles
Protein aggregation is a hallmark of neurodegenerative disorders. In this group of brain-related disorders, a disease-specific “host” protein or fragment misfolds and adopts a metastatic, aggregate-prone conformation. Often, this misfolded conformation is structurally and thermodynamically different...
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| Veröffentlicht in: | Biointerphases |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Vacuum Society
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5443695/ https://ncbi.nlm.nih.gov/pubmed/28539049 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1116/1.4984009 |
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