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The discovery of vemurafenib for the treatment of BRAF-mutated metastatic melanoma

INTRODUCTION: In the era of precision medicine and sophisticated modern genetics, the discovery of the BRAF(V600) inhibitor, vemurafenib, quickly became the model for targeted therapy in melanomas. As early as 2002, the majority of metastatic melanomas were described to harbor the BRAF(V600) mutatio...

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Bibliographic Details
Published in:Expert Opin Drug Discov
Main Authors: Kim, Alex, Cohen, Mark S.
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5443413/
https://ncbi.nlm.nih.gov/pubmed/27327499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/17460441.2016.1201057
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