Kinesin-5-independent mitotic spindle assembly requires the antiparallel microtubule crosslinker Ase1 in fission yeast

Bipolar spindle assembly requires a balance of forces where kinesin-5 produces outward pushing forces to antagonize the inward pulling forces from kinesin-14 or dynein. Accordingly, Kinesin-5 inactivation results in force imbalance leading to monopolar spindle and chromosome segregation failure. In...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Rincon, Sergio A., Lamson, Adam, Blackwell, Robert, Syrovatkina, Viktoriya, Fraisier, Vincent, Paoletti, Anne, Betterton, Meredith D., Tran, Phong T.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5442317/
https://ncbi.nlm.nih.gov/pubmed/28513584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15286
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