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The relationship between chain connectivity and domain stability in the equilibrium and kinetic folding mechanisms of dihydrofolate reductase from E.coli

The role of domains in defining the equilibrium and kinetic folding properties of dihydrofolate reductase (DHFR) from Escherichia coli was probed by examining the thermodynamic and kinetic properties of a set of variants in which the chain connectivity in the discontinuous loop domain (DLD) and the...

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Publicat a:Protein Eng Des Sel
Autors principals: Svensson, Anna-Karin E., Zitzewitz, Jill A., Matthews, C.Robert, Smith, Virginia F.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2006
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5441858/
https://ncbi.nlm.nih.gov/pubmed/16452118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzj017
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