Conditional knockin of Dnmt3a R878H initiates acute myeloid leukemia with mTOR pathway involvement

DNMT3A is frequently mutated in acute myeloid leukemia (AML). To explore the features of human AML with the hotspot DNMT3A R882H mutation, we generated Dnmt3a R878H conditional knockin mice, which developed AML with enlarged Lin(−)Sca1(+)cKit(+) cell compartments. The transcriptome and DNA methylati...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Dai, Yu-Jun, Wang, Yue-Ying, Huang, Jin-Yan, Xia, Li, Shi, Xiao-Dong, Xu, Jie, Lu, Jing, Su, Xian-Bin, Yang, Ying, Zhang, Wei-Na, Wang, Pan-Pan, Wu, Song-Fang, Huang, Ting, Mi, Jian-Qing, Han, Ze-Guang, Chen, Zhu, Chen, Sai-Juan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5441829/
https://ncbi.nlm.nih.gov/pubmed/28461508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1703476114
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