Human phosphatase CDC14A regulates actin organization through dephosphorylation of epithelial protein lost in neoplasm

CDC14 is an essential dual-specificity phosphatase that counteracts CDK1 activity during anaphase to promote mitotic exit in Saccharomyces cerevisiae. Surprisingly, human CDC14A is not essential for cell cycle progression. Instead, it regulates cell migration and cell adhesion. Little is known about...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Chen, Nan-Peng, Uddin, Borhan, Hardt, Robert, Ding, Wen, Panic, Marko, Lucibello, Ilaria, Kammerer, Patricia, Ruppert, Thomas, Schiebel, Elmar
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2017
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5441781/
https://ncbi.nlm.nih.gov/pubmed/28465438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1619356114
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