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Changes in the composition of brain interstitial ions control the sleep - wake cycle

Wakefulness is driven by the widespread release of neuromodulators by the ascending arousal system. Yet, it is unclear how these substances orchestrate state-dependent, global changes in neuronal activity. Here we show that neuromodulators induce increases in the extracellular K(+) concentration ([K...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Ding, Fengfei, O’Donnell, John, Xu, Qiwu, Kang, Ning, Goldman, Nanna, Nedergaard, Maiken
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5441687/
https://ncbi.nlm.nih.gov/pubmed/27126038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad4821
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