Concordance of bioactive vs. total immunoreactive serum leptin levels in children with severe early onset obesity

CONTEXT: Leptin secreted from adipose tissue signals peripheral energy status to the brain. Monogenic leptin deficiency results in severe early onset obesity with hyperphagia. Recently, a similar phenotype of inactivating leptin mutations but with preserved immunoreactivity and hence normal circulat...

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Publicado en:PLoS One
Main Authors: Stanik, Juraj, Kratzsch, Jürgen, Landgraf, Kathrin, Scheuermann, Kathrin, Spielau, Ulrike, Gausche, Ruth, Gasperikova, Daniela, Kiess, Wieland, Körner, Antje
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2017
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5441582/
https://ncbi.nlm.nih.gov/pubmed/28542631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0178107
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