Structural and mechanistic insights into homocysteine degradation by a mutant of methionine γ‐lyase based on substrate‐assisted catalysis

Methionine γ‐lyse (MGL) catalyzes the α, γ‐elimination of l‐methionine and its derivatives as well as the α, β‐elimination of l‐cysteine and its derivatives to produce α‐keto acids, volatile thiols, and ammonia. The reaction mechanism of MGL has been characterized by enzymological studies using seve...

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Vydáno v:Protein Sci
Hlavní autoři: Sato, Dan, Shiba, Tomoo, Yunoto, Shunsuke, Furutani, Kazuo, Fukumoto, Mitsuki, Kudou, Daizou, Tamura, Takashi, Inagaki, Kenji, Harada, Shigeharu
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
Témata:
Protein Structure Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5441414/
https://ncbi.nlm.nih.gov/pubmed/28329912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3158
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