Activation of STING-Dependent Innate Immune Signaling By S-Phase-Specific DNA Damage in Breast Cancer

Background: Previously we identified a DNA damage response–deficient (DDRD) molecular subtype within breast cancer. A 44-gene assay identifying this subtype was validated as predicting benefit from DNA-damaging chemotherapy. This subtype was defined by interferon signaling. In this study, we address...

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I publikationen:J Natl Cancer Inst
Huvudupphovsmän: Parkes, Eileen E., Walker, Steven M., Taggart, Laura E., McCabe, Nuala, Knight, Laura A., Wilkinson, Richard, McCloskey, Karen D., Buckley, Niamh E., Savage, Kienan I., Salto-Tellez, Manuel, McQuaid, Stephen, Harte, Mary T., Mullan, Paul B., Harkin, D. Paul, Kennedy, Richard D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2016
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Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5441301/
https://ncbi.nlm.nih.gov/pubmed/27707838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djw199
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