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Reexamination of the Physiological Role of PykA in Escherichia coli Revealed that It Negatively Regulates the Intracellular ATP Levels under Anaerobic Conditions

Pyruvate kinase is one of the three rate-limiting glycolytic enzymes that catalyze the last step of glycolysis, conversion of phosphoenolpyruvate (PEP) into pyruvate, which is associated with ATP generation. Two isozymes of pyruvate kinase, PykF and PykA, are identified in Escherichia coli. PykF is...

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Detalhes bibliográficos
Publicado no:Appl Environ Microbiol
Main Authors: Zhao, Chunhua, Lin, Zhao, Dong, Hongjun, Zhang, Yanping, Li, Yin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5440719/
https://ncbi.nlm.nih.gov/pubmed/28363967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.00316-17
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