Fluorination at the 4 position alters the substrate behavior of L-glutamine and L-glutamate: Implications for positron emission tomography of neoplasias

Two 4-fluoro-L-glutamine diastereoisomers [(2S,4R)-4-FGln, (2S,4S)-4-FGln] were previously developed for positron emission tomography. Label uptake into two tumor cell types was greater with [(18)F](2S,4R)-4-FGln than with [(18)F](2S,4S)-4-FGln. In the present work we investigated the enzymology of...

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Publicado no:J Fluor Chem
Main Authors: Jeitner, Thomas M., Kristoferson, Eva, Azcona, Juan A., Pinto, John T., Stalnecker, Clint, Erickson, Jon W., Kung, Hank F., Li, Jianyong, Ploessl, Karl, Cooper, Arthur J. L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5440087/
https://ncbi.nlm.nih.gov/pubmed/28546645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jfluchem.2016.10.008
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