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The metal nanoparticle-induced inflammatory response is regulated by SIRT1 through NF-κB deacetylation in aseptic loosening

Aseptic loosening is the most common cause of total hip arthroplasty (THA) failure, and osteolysis induced by wear particles plays a major role in aseptic loosening. Various pathways in multiple cell types contribute to the pathogenesis of osteolysis, but the role of Sirtuin 1 (SIRT1), which can reg...

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Détails bibliographiques
Publié dans:Int J Nanomedicine
Auteurs principaux: Deng, Zhantao, Jin, Jiewen, Wang, Zhenheng, Wang, Yong, Gao, Qian, Zhao, Jianning
Format: Artigo
Langue:Inglês
Publié: Dove Medical Press 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5439723/
https://ncbi.nlm.nih.gov/pubmed/28553103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S124661
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