Immune Signatures Following Single Dose Trastuzumab Predict Pathologic Response to Preoperative Trastuzumab and Chemotherapy in HER2-Positive Early Breast Cancer

PURPOSE: Recent data suggest that intrinsic subtype and immune cell infiltration may predict response to trastuzumab-based therapy. We studied the interaction between these factors, changes in immune signatures following brief exposure to trastuzumab, and achievement of pathologic complete response...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Varadan, Vinay, Gilmore, Hannah, Miskimen, Kristy L.S., Tuck, David, Parsai, Shikha, Awadallah, Amad, Krop, Ian E., Winer, Eric P., Bossuyt, Veerle, Somlo, George, Abu-Khalaf, Maysa M., Fenton, Mary Anne, Sikov, William, Harris, Lyndsay N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5439498/
https://ncbi.nlm.nih.gov/pubmed/26842237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2021
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