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Neurokinin 3 receptor antagonism as a novel treatment for menopausal hot flushes: a phase 2, randomised, double-blind, placebo-controlled trial

BACKGROUND: Hot flushes affect 70% of menopausal women and often severely impact physical, psychosocial, sexual, and overall wellbeing. Hormone replacement therapy is effective but is not without risk. Neurokinin B signalling is increased in menopausal women, and has been implicated as an important...

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Bibliografiske detaljer
Udgivet i:Lancet
Main Authors: Prague, Julia K, Roberts, Rachel E, Comninos, Alexander N, Clarke, Sophie, Jayasena, Channa N, Nash, Zachary, Doyle, Chedie, Papadopoulou, Deborah A, Bloom, Stephen R, Mohideen, Pharis, Panay, Nicholas, Hunter, Myra S, Veldhuis, Johannes D, Webber, Lorraine C, Huson, Les, Dhillo, Waljit S
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5439024/
https://ncbi.nlm.nih.gov/pubmed/28385352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0140-6736(17)30823-1
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