Neurokinin 3 receptor antagonism as a novel treatment for menopausal hot flushes: a phase 2, randomised, double-blind, placebo-controlled trial

BACKGROUND: Hot flushes affect 70% of menopausal women and often severely impact physical, psychosocial, sexual, and overall wellbeing. Hormone replacement therapy is effective but is not without risk. Neurokinin B signalling is increased in menopausal women, and has been implicated as an important...

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Pubblicato in:Lancet
Autori principali: Prague, Julia K, Roberts, Rachel E, Comninos, Alexander N, Clarke, Sophie, Jayasena, Channa N, Nash, Zachary, Doyle, Chedie, Papadopoulou, Deborah A, Bloom, Stephen R, Mohideen, Pharis, Panay, Nicholas, Hunter, Myra S, Veldhuis, Johannes D, Webber, Lorraine C, Huson, Les, Dhillo, Waljit S
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2017
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5439024/
https://ncbi.nlm.nih.gov/pubmed/28385352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0140-6736(17)30823-1
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