Cloning, chromosomal assignment, and regulation of the rat thyrotropin receptor: expression of the gene is regulated by thyrotropin, agents that increase cAMP levels, and thyroid autoantibodies.

A rat thyrotropin (thyroid-stimulating hormone, TSH) receptor cDNA was isolated that encoded a protein of 764 amino acids, Mr 86,528. Transfection of the cDNA caused COS-7 cells to develop a TSH-sensitive adenylate cyclase response and the ability to bind 125I-labeled TSH; both activities were simil...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Akamizu, T, Ikuyama, S, Saji, M, Kosugi, S, Kozak, C, McBride, O W, Kohn, L D
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1990
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54390/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1696008/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.15.5677
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