Identification of DNA-PKcs as a primary resistance factor of TIC10 in hepatocellular carcinoma cells

The current study tested the anti-hepatocellular carcinoma (HCC) cell activity of TIC10, a first-in-class small-molecule tumor necrosis (TNF)-related apoptosis-inducing ligand (TRAIL) inducer. TIC10 exerted potent anti-proliferative and pro-apoptotic actions in primary and established human HCC cell...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Cheng, Long, Liu, Yuan-yuan, Lu, Pei-Hua, Peng, Yi, Yuan, Qiang, Gu, Xin-shi, Jin, Yong, Chen, Min-Bin, Bai, Xu-ming
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2017
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5438657/
https://ncbi.nlm.nih.gov/pubmed/28415690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16073
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