Super-Enhancers and Broad H3K4me3 Domains Form Complex Gene Regulatory Circuits Involving Chromatin Interactions

Stretched histone regions, such as super-enhancers and broad H3K4me3 domains, are associated with maintenance of cell identity and cancer. We connected super-enhancers and broad H3K4me3 domains in the K562 chronic myelogenous leukemia cell line as well as the MCF-7 breast cancer cell line with chrom...

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Publicado no:Sci Rep
Main Authors: Cao, Fan, Fang, Yiwen, Tan, Hong Kee, Goh, Yufen, Choy, Jocelyn Yeen Hui, Koh, Bryan Thean Howe, Hao Tan, Jiong, Bertin, Nicolas, Ramadass, Aroul, Hunter, Ewan, Green, Jayne, Salter, Matthew, Akoulitchev, Alexandre, Wang, Wilson, Chng, Wee Joo, Tenen, Daniel G., Fullwood, Melissa J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5438348/
https://ncbi.nlm.nih.gov/pubmed/28526829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-02257-3
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