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Aggregation Effects and Population-based dynamics as a source of therapy resistance in cancer

OBJECTIVE: Evolution of resistance allows cancer cells to adapt and continue proliferating even when therapy is initially very effective. Most investigations of treatment resistance focus on the adaptive phenotypic properties of individual cells. We propose that the resistance of a single cell to th...

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Detalhes bibliográficos
Publicado no:IEEE Trans Biomed Eng
Main Authors: Brown, Joel S., Cunningham, Jessica J., Gatenby, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5438296/
https://ncbi.nlm.nih.gov/pubmed/28113286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1109/TBME.2016.2623564
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