TCF7L1 promotes skin tumorigenesis independently of β-catenin through induction of LCN2

The transcription factor TCF7L1 is an embryonic stem cell signature gene that is upregulated in multiple aggressive cancer types, but its role in skin tumorigenesis has not yet been defined. Here we document TCF7L1 upregulation in skin squamous cell carcinoma (SCC) and demonstrate that TCF7L1 overex...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Ku, Amy T, Shaver, Timothy M, Rao, Ajay S, Howard, Jeffrey M, Rodriguez, Christine N, Miao, Qi, Garcia, Gloria, Le, Diep, Yang, Diane, Borowiak, Malgorzata, Cohen, Daniel N, Chitsazzadeh, Vida, Diwan, Abdul H, Tsai, Kenneth Y, Nguyen, Hoang
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5438253/
https://ncbi.nlm.nih.gov/pubmed/28467300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.23242
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