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Linking hypoxia, DNA damage and proliferation in multicellular tumor spheroids

BACKGROUND: Multicellular Tumor Spheroids are frequently used to mimic the regionalization of proliferation and the hypoxic environment within avascular tumors. Here we exploit these features to study the activation of DNA damage repair pathways and their correlation to developing hypoxia. METHODS:...

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Bibliografske podrobnosti
izdano v:BMC Cancer
Main Authors: Riffle, Stephen, Pandey, Ram Naresh, Albert, Morgan, Hegde, Rashmi S.
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437385/
https://ncbi.nlm.nih.gov/pubmed/28521819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-017-3319-0
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