trans-Fatty acids promote proinflammatory signaling and cell death by stimulating the apoptosis signal-regulating kinase 1 (ASK1)-p38 pathway

Food-borne trans-fatty acids (TFAs) are mainly produced as byproducts during food manufacture. Recent epidemiological studies have revealed that TFA consumption is a major risk factor for various disorders, including atherosclerosis. However, the underlying mechanisms in this disease etiology are la...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Hirata, Yusuke, Takahashi, Miki, Kudoh, Yuki, Kano, Kuniyuki, Kawana, Hiroki, Makide, Kumiko, Shinoda, Yasuharu, Yabuki, Yasushi, Fukunaga, Kohji, Aoki, Junken, Noguchi, Takuya, Matsuzawa, Atsushi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437226/
https://ncbi.nlm.nih.gov/pubmed/28360100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.771519
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