Mimicking Cardiac Fibrosis in a Dish: Fibroblast Density Rather than Collagen Density Weakens Cardiomyocyte Function

Cardiac fibrosis is one of the most devastating effects of cardiac disease. Current in vitro models of cardiac fibrosis do not sufficiently mimic the complex in vivo environment of the cardiomyocyte. We determined the local composition and mechanical properties of the myocardium in established mouse...

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Publicado en:J Cardiovasc Transl Res
Autores principales: van Spreeuwel, Ariane C.C., Bax, Noortje A.M., van Nierop, Bastiaan J., Aartsma-Rus, Annemieke, Goumans, Marie-José T.H., Bouten, Carlijn V.C.
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer US 2017
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437129/
https://ncbi.nlm.nih.gov/pubmed/28281243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12265-017-9737-1
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