Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression

The senescence of mammalian cells is characterized by a proliferative arrest in response to stress and the expression of an inflammatory phenotype. Here we show that histone H2A.J, a poorly studied H2A variant found only in mammals, accumulates in human fibroblasts in senescence with persistent DNA...

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Vydáno v:Nat Commun
Hlavní autoři: Contrepois, Kévin, Coudereau, Clément, Benayoun, Bérénice A., Schuler, Nadine, Roux, Pierre-François, Bischof, Oliver, Courbeyrette, Régis, Carvalho, Cyril, Thuret, Jean-Yves, Ma, Zhihai, Derbois, Céline, Nevers, Marie-Claire, Volland, Hervé, Redon, Christophe E., Bonner, William M., Deleuze, Jean-François, Wiel, Clotilde, Bernard, David, Snyder, Michael P., Rübe, Claudia E., Olaso, Robert, Fenaille, François, Mann, Carl
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5436145/
https://ncbi.nlm.nih.gov/pubmed/28489069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14995
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