TNFα drives mitochondrial stress in POMC neurons in obesity

Consuming a calorically dense diet stimulates microglial reactivity in the mediobasal hypothalamus (MBH) in association with decreased number of appetite-curbing pro-opiomelanocortin (POMC) neurons; whether the reduction in POMC neuronal function is secondary to the microglial activation is unclear....

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Publicado en:Nat Commun
Main Authors: Yi, Chun-Xia, Walter, Marc, Gao, Yuanqing, Pitra, Soledad, Legutko, Beata, Kälin, Stefanie, Layritz, Clarita, García-Cáceres, Cristina, Bielohuby, Maximilian, Bidlingmaier, Martin, Woods, Stephen C., Ghanem, Alexander, Conzelmann, Karl-Klaus, Stern, Javier E., Jastroch, Martin, Tschöp, Matthias H.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5436136/
https://ncbi.nlm.nih.gov/pubmed/28489068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15143
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