Amphetamine and Methamphetamine Increase NMDAR-GluN2B Synaptic Currents in Midbrain Dopamine Neurons

The psychostimulants amphetamine (AMPH) and methamphetamine (MA) are widely abused illicit drugs. Here we show that both psychostimulants acutely increase NMDA receptor (NMDAR)-mediated synaptic currents and decrease AMPA receptor (AMPAR)/NMDAR ratios in midbrain dopamine neurons. The potentiation d...

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Pubblicato in:Neuropsychopharmacology
Autori principali: Li, Ming-Hua, Underhill, Suzanne M, Reed, Cheryl, Phillips, Tamara J, Amara, Susan G, Ingram, Susan L
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5436114/
https://ncbi.nlm.nih.gov/pubmed/27976681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2016.278
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