Nuclear uptake of an amino-terminal fragment of apolipoprotein E4 promotes cell death and localizes within microglia of the Alzheimer’s disease brain

Although harboring the apolipoprotein E4 (APOE4) allele is a well known risk factor in Alzheimer’s disease (AD), the mechanism by which it contributes to disease risk remains elusive. To investigate the role of proteolysis of apoE4 as a potential mechanism, we designed and characterized a site-direc...

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Bibliographic Details
Published in:Int J Physiol Pathophysiol Pharmacol
Main Authors: Love, Julia E, Day, Ryan J, Gause, Justin W, Brown, Raquel J, Pu, Xinzhu, Theis, Dustin I, Caraway, Chad A, Poon, Wayne W, Rahman, Abir A, Morrison, Brad E, Rohn, Troy T
Format: Artigo
Language:Inglês
Published: e-Century Publishing Corporation 2017
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5435672/
https://ncbi.nlm.nih.gov/pubmed/28533891
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