A nonsense mutation in TLR5 is associated with survival and reduced IL-10 and TNF-α levels in human melioidosis

BACKGROUND: Melioidosis, caused by the flagellated bacterium Burkholderia pseudomallei, is a life-threatening and increasingly recognized emerging disease. Toll-like receptor (TLR) 5 is a germline-encoded pattern recognition receptor to bacterial flagellin. We evaluated the association of a nonsense...

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Detalhes bibliográficos
Publicado no:PLoS Negl Trop Dis
Main Authors: Chaichana, Panjaporn, Chantratita, Narisara, Brod, Florian, Koosakulnirand, Sirikamon, Jenjaroen, Kemajittra, Chumseng, Suchintana, Sumonwiriya, Manutsanun, Burtnick, Mary N., Brett, Paul J., Teparrukkul, Prapit, Limmathurotsakul, Direk, Day, Nicholas P. J., Dunachie, Susanna J., West, T. Eoin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5435357/
https://ncbi.nlm.nih.gov/pubmed/28475641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0005587
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