Targeting hexokinase 2 inhibition promotes radiosensitization in HPV16 E7-induced cervical cancer and suppresses tumor growth

In order to improve the sensitivity of cervical cancer cells to irradiation therapy, we targeted hexokinase 2 (HK2), the first rate-limiting enzyme of glycolysis, and explore its role in cervical cancer cells. We suppressed HK2 expression and/or function by shRNA and/or metformin and found HK2 inhib...

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Veröffentlicht in:Int J Oncol
Hauptverfasser: Liu, Yuan, Murray-Stewart, Tracy, Casero, Robert A., Kagiampakis, Ioannis, Jin, Lihua, Zhang, Jiawen, Wang, Huihui, Che, Qi, Tong, Huan, Ke, Jieqi, Jiang, Feizhou, Wang, Fangyuan, Wan, Xiaoping
Format: Artigo
Sprache:Inglês
Veröffentlicht: D.A. Spandidos 2017
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5435328/
https://ncbi.nlm.nih.gov/pubmed/28498475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2017.3979
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