Pioglitazone together with imatinib in chronic myeloid leukemia: A proof of concept study

BACKGROUND: We recently reported that peroxisome proliferator‐activated receptor γ agonists target chronic myeloid leukemia (CML) quiescent stem cells in vitro by decreasing transcription of STAT5. Here in the ACTIM phase 2 clinical trial, we asked whether pioglitazone add‐on therapy to imatinib wou...

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Veröffentlicht in:Cancer
Hauptverfasser: Rousselot, Philippe, Prost, Stéphane, Guilhot, Joelle, Roy, Lydia, Etienne, Gabriel, Legros, Laurence, Charbonnier, Aude, Coiteux, Valérie, Cony‐Makhoul, Pascale, Huguet, Francoise, Cayssials, Emilie, Cayuela, Jean‐Michel, Relouzat, Francis, Delord, Marc, Bruzzoni‐Giovanelli, Heriberto, Morisset, Laure, Mahon, François‐Xavier, Guilhot, François, Leboulch, Philippe
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2016
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5434901/
https://ncbi.nlm.nih.gov/pubmed/28026860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.30490
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