Highly polygenic architecture of antidepressant treatment response: Comparative analysis of SSRI and NRI treatment in an animal model of depression

Response to antidepressant (AD) treatment may be a more polygenic trait than previously hypothesized, with many genetic variants interacting in yet unclear ways. In this study we used methods that can automatically learn to detect patterns of statistical regularity from a sparsely distributed signal...

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Publicado en:Am J Med Genet B Neuropsychiatr Genet
Autores principales: Malki, Karim, Tosto, Maria Grazia, Mouriño‐Talín, Héctor, Rodríguez‐Lorenzo, Sabela, Pain, Oliver, Jumhaboy, Irfan, Liu, Tina, Parpas, Panos, Newman, Stuart, Malykh, Artem, Carboni, Lucia, Uher, Rudolf, McGuffin, Peter, Schalkwyk, Leonard C., Bryson, Kevin, Herbster, Mark
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2016
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5434854/
https://ncbi.nlm.nih.gov/pubmed/27696737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajmg.b.32494
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