Highly polygenic architecture of antidepressant treatment response: Comparative analysis of SSRI and NRI treatment in an animal model of depression

Response to antidepressant (AD) treatment may be a more polygenic trait than previously hypothesized, with many genetic variants interacting in yet unclear ways. In this study we used methods that can automatically learn to detect patterns of statistical regularity from a sparsely distributed signal...

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Veröffentlicht in:Am J Med Genet B Neuropsychiatr Genet
Hauptverfasser: Malki, Karim, Tosto, Maria Grazia, Mouriño‐Talín, Héctor, Rodríguez‐Lorenzo, Sabela, Pain, Oliver, Jumhaboy, Irfan, Liu, Tina, Parpas, Panos, Newman, Stuart, Malykh, Artem, Carboni, Lucia, Uher, Rudolf, McGuffin, Peter, Schalkwyk, Leonard C., Bryson, Kevin, Herbster, Mark
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2016
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5434854/
https://ncbi.nlm.nih.gov/pubmed/27696737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajmg.b.32494
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