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Thiopurine use associated with reduced B and natural killer cells in inflammatory bowel disease

AIM: To identify which blood and mucosal lymphocyte populations are specifically depleted by thiopurine use in vivo. METHODS: The thiopurines azathioprine and 6-mercaptopurine have been a mainstay of inflammatory bowel disease (IBD) therapy for decades, but their mechanism of action in vivo remains...

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Detalhes bibliográficos
Publicado no:World J Gastroenterol
Main Authors: Lord, James D, Shows, Donna M
Formato: Artigo
Idioma:Inglês
Publicado em: Baishideng Publishing Group Inc 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5434429/
https://ncbi.nlm.nih.gov/pubmed/28566883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v23.i18.3240
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