New Modified UPLC/Tandem Mass Spectrometry Method for Determination of Risperidone and Its Active Metabolite 9-Hydroxyrisperidone in Plasma: Application to Dose-Dependent Pharmacokinetic Study in Sprague-Dawley Rats

Sensitive and specific liquid-chromatography tandem mass spectrometry (UPLC-MS/MS) assay has been developed and validated for simultaneous quantification of risperidone (RIS) and its active metabolite 9-hydroxyrisperidone (9-OH-RIS) in rat plasma using olanzapine (OLA) as internal standard (IS). Pha...

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Detalhes bibliográficos
Publicado no:Int J Anal Chem
Main Authors: Ezzeldin, Essam, Tammam, Marwa, Abo Talib, Nisreen F.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5434277/
https://ncbi.nlm.nih.gov/pubmed/28553353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/1271383
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