Extracellular Signal-Regulated Kinases Phosphorylate Mitogen-Activated Protein Kinase Phosphatase 3/DUSP6 at Serines 159 and 197, Two Sites Critical for Its Proteasomal Degradation

Mitogen-activated protein (MAP) kinase phosphatases (MKPs) are dual-specificity phosphatases that dephosphorylate phosphothreonine and phosphotyrosine residues within MAP kinases. Here, we describe a novel posttranslational mechanism for regulating MKP-3/Pyst1/DUSP6, a member of the MKP family that...

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Detalhes bibliográficos
Main Authors: Marchetti, Sandrine, Gimond, Clotilde, Chambard, Jean-Claude, Touboul, Thomas, Roux, Danièle, Pouysségur, Jacques, Pagès, Gilles
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC543408/
https://ncbi.nlm.nih.gov/pubmed/15632084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.2.854-864.2005
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