Chromosome 17p deletions and p53 gene mutations associated with the formation of malignant neurofibrosarcomas in von Recklinghausen neurofibromatosis.

von Recklinghausen neurofibromatosis (NF1) is a common hereditary disorder characterized by neural crest-derived tumors, particularly benign neurofibromas whose malignant transformation to neurofibrosarcomas can be fatal. The NF1 gene has been mapped to a small region of chromosome 17q, but neither...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Menon, A G, Anderson, K M, Riccardi, V M, Chung, R Y, Whaley, J M, Yandell, D W, Farmer, G E, Freiman, R N, Lee, J K, Li, F P
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1990
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54339/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2142531/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.14.5435
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