Loss of the TGF-β Effector β2SP Promotes Genomic Instability

Exposure to genotoxins such as ethanol-derived acetaldehyde leads to DNA damage and liver injury, and promotes the development of cancer. We report here a major role for the TGF-β/Smad3 adaptor β2-Spectrin (β2SP, gene Sptbn1) in maintaining genomic stability following alcohol-induced DNA damage. β2S...

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Detaylı Bibliyografya
Yayımlandı:Hepatology
Asıl Yazarlar: Chen, Jian, Shukla, Vivek, Farci, Patrizia, Andricovich, Jaclyn, Jogunoori, Wilma, Kwong, Lawrence N, Katz, Lior H., Shetty, Kirti, Rashid, Asif, Su, Xiaoping, White, Jon, Li, Lei, Wang, Alan Yaoqi, Blechacz, Boris, Raju, Gottumukkala S., Davila, Marta, Nguyen, Bao-Ngoc, Stroehlein, John R., Chen, Junjie, Kim, Sang Soo, Levin, Heather, Machida, Keigo, Tsukamoto, Hidekazu, Michaely, Peter, Tzatsos, Alexandros, Mishra, Bibhuti, Amdur, Richard, Mishra, Lopa
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5432427/
https://ncbi.nlm.nih.gov/pubmed/28114741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.28927
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