EGFR mediates activation of RET in lung adenocarcinoma with neuroendocrine differentiation characterized by ASCL1 expression

Achaete-scute homolog 1 (ASCL1) is a neuroendocrine transcription factor specifically expressed in 10-20% of lung adenocarcinomas (AD) with neuroendocrine (NE) differentiation (NED). ASCL1 functions as an upstream regulator of the RET oncogene in AD with high ASCL1 expression (A(+)AD). RET is a rece...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Bhinge, Kaustubh, Yang, Lin, Terra, Simone, Nasir, Aqsa, Muppa, Prasuna, Aubry, Marie Christine, Yi, Joanne, Janaki, Nafiseh, Kovtun, Irina V., Murphy, Stephen J., Halling, Geoffrey, Rahi, Hamed, Mansfield, Aaron, de Andrade, Mariza, Yang, Ping, Vasmatzis, George, Peikert, Tobias, Kosari, Farhad
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5432325/
https://ncbi.nlm.nih.gov/pubmed/28460442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15676
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