Hispidin induces autophagic and necrotic death in SGC-7901 gastric cancer cells through lysosomal membrane permeabilization by inhibiting tubulin polymerization

Hispidin and its derivatives are widely distributed in edible mushrooms. Hispidin is more cytotoxic to A549, SCL-1, Bel7402 and Capan-1 cancer cells than to MRC5 normal cells; by contrast, hispidin protects H9c2 cardiomyoblast cells from hydrogen peroxide-induced or doxorubicin-induced apoptosis. Co...

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Vydáno v:Oncotarget
Hlavní autoři: Lv, Long-Xian, Zhou, Zhen-Xing, Zhou, Zhan, Zhang, Li-Jiang, Yan, Ren, Zhao, Zhao, Yang, Li-Ya, Bian, Xiao-Yuan, Jiang, Hui-Yong, Li, Yu-Dong, Sun, Yi-Sheng, Xu, Qin-Qin, Hu, Gui-Li, Guan, Wen-Jun, Li, Yong-Quan
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5432313/
https://ncbi.nlm.nih.gov/pubmed/28460485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15935
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