Investigation of cationicity and structure of pseudin-2 analogues for enhanced bacterial selectivity and anti-inflammatory activity

Pseudin-2 (Ps), isolated from the frog Pseudis paradoxa, exhibits potent antibacterial activity and cytotoxicity. To develop antimicrobial peptides with anti-inflammatory activity and low cytotoxicity, we designed Ps analogues with Lys substitutions, resulting in elevated amphipathic α-helical struc...

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Vydáno v:Sci Rep
Hlavní autoři: Jeon, Dasom, Jeong, Min-Cheol, Jacob, Binu, Bang, Jeong Kyu, Kim, Eun-Hee, Cheong, Chaejoon, Jung, In Duk, Park, Yoonkyung, Kim, Yangmee
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5431190/
https://ncbi.nlm.nih.gov/pubmed/28469145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-01474-0
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