Sequence variation in Plasmodium falciparum Histidine Rich Proteins 2 and 3 in Indian isolates: Implications for Malaria Rapid Diagnostic Test Performance

Commercial malaria rapid diagnostic tests (RDTs) detect P. falciparum histidine rich protein 2 (PfHRP2) and cross react with PfHRP3, a structural homologue. Here, we analysed natural variations in PfHRP2 and PfHRP3 sequences from Indian isolates and correlated these variations with RDT reactivity. A...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Kumar Bharti, Praveen, Singh Chandel, Himanshu, Krishna, Sri, Nema, Shrikant, Ahmad, Amreen, Udhayakumar, Venkatachalam, Singh, Neeru
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5430971/
https://ncbi.nlm.nih.gov/pubmed/28465622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-01506-9
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