Sulfated Hyaluronan Derivatives Modulate TGF-β1:Receptor Complex Formation: Possible Consequences for TGF-β1 Signaling

Glycosaminoglycans are known to bind biological mediators thereby modulating their biological activity. Sulfated hyaluronans (sHA) were reported to strongly interact with transforming growth factor (TGF)-β1 leading to impaired bioactivity in fibroblasts. The underlying mechanism is not fully elucida...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Koehler, Linda, Samsonov, Sergey, Rother, Sandra, Vogel, Sarah, Köhling, Sebastian, Moeller, Stephanie, Schnabelrauch, Matthias, Rademann, Jörg, Hempel, Ute, Pisabarro, M. Teresa, Scharnweber, Dieter, Hintze, Vera
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5430790/
https://ncbi.nlm.nih.gov/pubmed/28446792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-01264-8
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