Phosphorylation of the mitochondrial autophagy receptor Nix enhances its interaction with LC3 proteins

The mitophagy receptor Nix interacts with LC3/GABARAP proteins, targeting mitochondria into autophagosomes for degradation. Here we present evidence for phosphorylation-driven regulation of the Nix:LC3B interaction. Isothermal titration calorimetry and NMR indicate a ~100 fold enhanced affinity of t...

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Publicado en:Sci Rep
Main Authors: Rogov, Vladimir V., Suzuki, Hironori, Marinković, Mija, Lang, Verena, Kato, Ryuichi, Kawasaki, Masato, Buljubašić, Maja, Šprung, Matilda, Rogova, Natalia, Wakatsuki, Soichi, Hamacher-Brady, Anne, Dötsch, Volker, Dikic, Ivan, Brady, Nathan R., Novak, Ivana
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5430633/
https://ncbi.nlm.nih.gov/pubmed/28442745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-01258-6
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