Neurons Export Extracellular Vesicles Enriched in Cysteine String Protein and Misfolded Protein Cargo

The fidelity of synaptic transmission depends on the integrity of the protein machinery at the synapse. Unfolded synaptic proteins undergo refolding or degradation in order to maintain synaptic proteostasis and preserve synaptic function, and buildup of unfolded/toxic proteins leads to neuronal dysf...

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Pubblicato in:Sci Rep
Autori principali: Deng, Jingti, Koutras, Carolina, Donnelier, Julien, Alshehri, Mana, Fotouhi, Maryam, Girard, Martine, Casha, Steve, McPherson, Peter S., Robbins, Stephen M., Braun, Janice E. A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5430488/
https://ncbi.nlm.nih.gov/pubmed/28424476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-01115-6
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