Discovery of Fluorine-Containing Benzoxazinyl-oxazolidinones for the Treatment of Multidrug Resistant Tuberculosis

[Image: see text] A novel series of fluorine-containing benzoxazinyl-oxazolidinones were designed and synthesized as antidrug-resistant tuberculosis agents possessing good activity and improved pharmacokinetic profiles. Compound 21 exhibited not only outstanding in vitro activity with a MIC value of...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Zhao, Hongyi, Lu, Yu, Sheng, Li, Yuan, Zishuo, Wang, Bin, Wang, Weiping, Li, Yan, Ma, Chen, Wang, Xiaoliang, Zhang, Dongfeng, Huang, Haihong
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5430409/
https://ncbi.nlm.nih.gov/pubmed/28523106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00068
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