Identification of New FLT3 Inhibitors That Potently Inhibit AML Cell Lines via an Azo Click-It/Staple-It Approach

[Image: see text] Acute myeloid leukemia (AML) is an aggressive malignancy with only a handful of therapeutic options. About 30% of AML patients harbor mutated FLT3 kinase, and thus, this cancer-driver has become a hotly pursued AML target. Herein we report a new class of FLT3 inhibitors, which pote...

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Gepubliceerd in:ACS Med Chem Lett
Hoofdauteurs: Ma, Xiaochu, Zhou, Jie, Wang, Changhao, Carter-Cooper, Brandon, Yang, Fan, Larocque, Elizabeth, Fine, Jonathan, Tsuji, Genichiro, Chopra, Gaurav, Lapidus, Rena G., Sintim, Herman O.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Chemical Society 2017
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5430396/
https://ncbi.nlm.nih.gov/pubmed/28523099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00468
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